Module LS4110 B

Duration

1 Semester

Turnus of offer

each summer semester

Credit points

3

Course of studies, specific fields and terms:

• Master Molecular Life Science 2023, Module part of a compulsory module, structure biology
• Master MLS 2018, Module part of a compulsory module, cell biology
• Master MLS 2016, Module part of a compulsory module, cell biology
• Master MLS 2009, Module part of a compulsory module, structure biology

Classes and lectures:

• Drug Design (lecture, 2 SWS)

Workload:

• 60 hours private studies
• 30 hours in-classroom work

Contents of teaching:

• Drug Discovery - An Overview
• Target identification and validation
• X-ray Crystallography in Drug Design
• Structure-based drug design - Principles and Methods
• Examples of structure-based Drug Design
• NMR experiments in Drug Design
• Chemical Synthesis of Drugs - Combinatorial Approaches

Qualification-goals/Competencies:

• The students know basic strategies of Drug Design and are able to explain them.
• They know the way from the target discovery to the drug and the techniques of rational Drug Design.
• They know NMR and X-ray Crystallography as important tools for target monitoring and optimization and are able to explain them.
• The students know the relationship between chemical structure and effect and the techniques for theoretical prognosis and experimental tests, particular X-ray crystallography and NMR-experiments.
• The students understand concepts of synthesis and are able to assess their application in Drug Design.
• The students know the borders of X-ray crystallography and NMR-experiments.

Grading through:

• written exam

Responsible for this module:

• Dr. Alvaro Mallagaray

Teacher:

• Institute of Biochemistry
• Institute of Chemistry and Metabolomics
• Dr. Alvaro Mallagaray
• Prof. Dr. Lars Redecke

Literature:

• G. Klebe : Wirkstoffdesign Spektrum-Verlag Heidelberg, 2009. ISBN 978-3-8274-2046-6
• C.G. Wermuth, D. Aldous, P. Raboisson, D. Roynan : The Practice of Medicinal Chemistry, 4th Ed., Academic Press, 2015
• : Grundlagen- und Übersichtsartikel für beide Veranstaltungen

Language:

• English, except in case of only German-speaking participants

Notes:

Last Updated:

21.03.2024