Module EW4170-KP04

Duration

1 Semester

Turnus of offer

each winter semester

Credit points

4

Course of studies, specific fields and terms:

• Master Molecular Life Science 2023, optional subject, life sciences

Classes and lectures:

• Introduction to classic and translational system biology (exercise, 2 SWS)
• Introduction to classic and translational system biology (lecture, 2 SWS)

Workload:

• 60 hours in-classroom work
• 60 hours private studies

Contents of teaching:

• Introduction to the genome and proteome of cellular systems
• Networks: cellular, genetic, gene-regulatory networks, interactomes
• Analysis of dynamical systems: fixed points, bifurcations and feedback
• Bioinformatic analysis of “Omics” data
• Introduction to public databases: e.g. STRING, Gene Expression Omnibus, TCGA, KEGG, Reactome, MSigDB
• Exercises: computer lab for analysis of dynamical systems and cellular pathways in R
• Exercises: Practical exercises on the analysis of dynamical systems and cellular signaling pathways
• Exercises on the solution of differential equations

Qualification-goals/Competencies:

• The students can explain the principles of signal transduction in the cell
• The students can relate to the genome, transcriptome, interactome and proteome
• They can analyse and characterize dynamical systems
• They know common methods to analyse high-throughput data
• Lab work will enable the students to continue studying this subject on their own

Grading through:

• written exam

Responsible for this module:

• Prof. Dr. Hauke Busch

Teacher:

• LIED | Lübecker Institut für experimentelle Dermatologie (Lübeck Institute of Experimental Dermatology)
• Prof. Dr. Hauke Busch
• Dr. Axel Künstner
• MitarbeiterInnen des Instituts

Literature:

• Marian Walhout, Marc Vidal, Job Dekker : Handbook of Systems Biology: Concepts and Insights (Englisch) Gebundene Ausgabe – 15. November 2012
• Edda Klipp, Wolfram Liebermeister, Christoph Wierling, Axel Kowald; : Systems Biology: A Textbook Englisch) Taschenbuch – 20. April 2016
• Yoram Vodovotz and Gary : An Translational Systems Biology, Concepts and Practice for the Future of Biomedical Research

Language:

• offered only in English

Notes:

Last Updated:

27.09.2021