Module MZ5111-KP06

Duration

1 Semester

Turnus of offer

each winter semester

Credit points

6

Course of studies, specific fields and terms:

• Master Infection Biology 2023, compulsory, Immunology
• Master Nutritional Medicine 2023, Module part of a compulsory module, life sciences
• Master Molecular Life Science 2023, optional subject, Immunology
• Master MLS 2018, optional subject, Immunology
• Master Nutritional Medicine 2019, Module part of a compulsory module, life sciences
• Master MLS 2016, optional subject, cell biology

Classes and lectures:

• Immunology (seminar, 2 SWS)
• Immunology (lecture, 2 SWS)

Workload:

• 60 hours in-classroom work
• 120 hours private studies

Contents of teaching:

• Lecture: Introduction to immunology
• Cells of the innate immune system
• Innate immune system: pathogen recognition
• Complement and inflammation
• Introduction into the adaptive immune system
• Antigen-presentation and T cell activation
• Immunological memory
• Immune system and infektion I: bacteria, worms, fungi
• Immune system and infektion II: Viruses
• Signal transduktion in immune cells
• Organs and tissues of the immune system, homing
• Immunpathogenesis I: allergy and asthma
• Immunpathogenesis II: autoimmune diseases
• Immunprivileged Organs
• Hematopoiesis and hematopoietic stem cells
• Experimental and clinically applied biologicals
• Seminar: PCR
• ELISA/ELISPOT
• Flow cytometry I: FACS-Analysis
• Flow cytometry II: MACS, FACS-Sort
• Flow cytometry III: Practical course at the ISEF (MACS, Analysis, Sort)
• Conventional and confocal microscopy
• Methods in signal transduction
• Migration: transwell assay; adhesion test etc.
• 2-Photon microscopy
• Animal models in life science
• Genetically modified mice I: conventional transgenics and KO mice
• Genetically modified mice II: conditional KO und Knock In Mice

Qualification-goals/Competencies:

• Students are able to:
• Name cells of the immune system and allocate their functions
• Name organs that belong to the immune system and allocate their functions
• Name mechanisms, cells and molecules of the innate and adaptive immune system and allocate their functions during bacterial, viral and fungal infections
• Name and allocate functions of molecules important for B cell -T cell co-cooperation
• Name and allocate the functions of molecules and antigen-presenting cells important for T cell activation and differentiation
• Name molecules of the complement system and allocate their functions for immune protection and immune diseases
• Name structure and function of the distinct antibody classes
• Name and allocate functions of molecules important for homing and migration of immune cells
• Name and allocate functions of molecules important for the initiation and resolution of inflammation
• Name the functions of immunological memory
• Name molecules and mechanisms involved in the development of B cell and T cell memory
• Describe the principal sequence of an immune reaction during infection and after vaccination
• Name genetic, molecular and cellular disturbances of the immune system relevant for immune deficiency, autoimmune and allergic diseases
• Describe the basic mechanisms of signal transduction in immune cells
• Name mechanisms and molecules involved in hematopoiesis
• Name and explain immunological methods
• Present and discuss scientific data

Grading through:

• written exam

Responsible for this module:

• Prof. Dr. rer. nat. Christian Karsten

Teacher:

• Institute for Systemic Inflammation Research (ISEF)
• Prof. Dr. rer. nat. Rudolf Manz
• Prof. Dr. med. Jörg Köhl
• Prof. Dr. rer. nat. Christian Karsten
• Prof. Dr. Admar Verschoor
• PD Dr. rer. nat. Yves Laumonnier

Literature:

• Janeway, Travers, Walport, Shlomchik : Janeway's Immunobiology Routledge Chapman Hall
• : original and review articles

Language:

• offered only in English

Notes:

Last Updated:

21.04.2021