Module LS2300-KP08, LS2301

Duration

1 Semester

Turnus of offer

each summer semester

Credit points

8

Course of studies, specific fields and terms:

• Master CLS 2023, compulsory, MML with specialization in Life Science
• Bachelor Molecular Life Science 2024, compulsory, Chemistry
• Bachelor MLS 2018, compulsory, Chemistry
• Bachelor MLS 2016, compulsory, Chemistry
• Master CLS 2016, compulsory, MML with specialization in Life Science
• Bachelor Biophysics 2016, compulsory, biophysics
• Master CLS 2010, optional subject, computational life science / life sciences
• Bachelor MLS 2009, compulsory, life sciences

Classes and lectures:

• Biophysical Chemistry (practical course, 3 SWS)
• Biophysical Chemistry (exercise, 1 SWS)
• Biophysical Chemistry (lecture, 3 SWS)

Workload:

• 80 hours in-classroom work
• 160 hours private studies

Contents of teaching:

• Lecture topics:
• What is Biophysical Chemistry?
• Basics of NMR spectroscopy
• Basics of mass spectrometry
• Theoretical calculation of molecules - Quantum mechanics or molecular mechanics?
• Basics of chemical thermodynamics
• Thermodynamics of ligand binding
• Basics of chemical kinetics
• Basics of enzyme kinetics
• Molecular Mechanics
• Practical works:
• NMR, Molecular Modeling, experiments with a focus on thermodynamics and kinetics

Qualification-goals/Competencies:

• Acquire basic knowledge on spectroscopic techniques to analyze (bio)molecules. Focus is on NMR and mass spectrometry techniques
• Insight into properties (e.g. structure, dynamics, spectroscopic properties) of molecules employing theoretical models. Acquisition of basic knowledge to compute molecules
• Application of laws of thermodynamics to describe chemical reactions and biological processes with a focus on binding and recognition reactions in biological systems
• Acquire basic knowledge to analyze time courses of chemical reactions and biological processes
• Acquisition of skills to work independently and self-determined in the laboratory with regard to the roles of GSP of the University of Lübeck and of the DFG-guidelines.

Grading through:

• written exam

Requires:

• Organic Chemistry (LS1600-KP10, LS1600-MLS)

Responsible for this module:

• Prof. Dr. rer. nat. Ulrich Günther

Teacher:

• Institute of Chemistry and Metabolomics
• Prof. Dr. rer. nat. Ulrich Günther
• PD Dr. phil. nat. Thomas Weimar

Literature:

• Peter Atkins and Julio de Paula : Physical Chemistry for the Life Sciences Oxford, University Press, Freeman and Company, 2006, ISBN 0-1992-8095-9
• Thomas Engel und Philip Reid : Physikalische Chemie Pearson Studium, 2006, ISBN 13: 978-3-8273-7200-0
• van Holde, Johnson & HoPrentice Hall : Principles of Physical Biochemistry New Jersey, 1998, 2006, ISBN 0-13-720459-0
• Atkins : Physical Chemistry Oxford University Press, Oxford Mel-bourne Tokyo, 1998, ISBN 0-19-850101-3 Paperback, Deutsche Ausgabe (dritte Auflage) bei Wiley VCH, 2002: ISBN 3-527-30236-0 Wiley-VCH, Weinheim
• Fersht, W. H. : Structure and Mechanism in Protein Science New York, 1999, ISBN 0-7167-3268-8
• Cantor & Schimmel : Biophysical Chemistry, Parts I-III Freeman and Company, New York, 1980, ISBN 0-71671188-5 Paperback
• H. Friebolin : Ein- und zweidimensionale NMR-Spektroskopie Wiley-VCH
• James Keeler and Peter Wothers : Chemical Structure and Reactivity: An integrated approach Oxford University Press, 2008; second ed. 2013 /li>

Language:

• offered only in German

Notes:

Last Updated:

11.04.2024