Module LS4031-KP12

Duration

2 Semester

Turnus of offer

starts every winter semester

Credit points

12

Course of studies, specific fields and terms:

• Master Biophysics 2023, advanced module, advanced curriculum
• Master Biophysics 2019, advanced module, advanced curriculum

Classes and lectures:

• General virology and biosafety (= LS4040) (lecture, 2 SWS)
• Pharmakologie und Toxikologie (= LS4110 A) (lecture, 2 SWS)
• Drug Design ( = LS4110 B) (lecture, 2 SWS)
• Cell Biology (= LS4010 A) (lecture, 2 SWS)

Workload:

• 120 hours in-classroom work
• 240 hours private studies

Contents of teaching:

• Similar to LS4110A, LS4110B, LS4010A, LS4040: Introduction into Pharmacology
• Pharmacodynamic
• Pharmacokinetics
• Oral Antidiabetics
• Pharmacology of the Renin-Angiotensin-Aldosterone-System
• Cerebrovascular Pharmacology
• Reverse Pharmacology
• Pharmacology of the Blood-Brain-Barrier
• Anxiolytics, Hypnotics and Sedatives
• Antiepileptic Drugs
• Gene Therapy of neurological diseases
• Pain physiology and analgetic therapies
• Concepts in Drug Design
• NMR experiments for Drug Design
• Case Study: Omeprazole vs. Tamiflu
• Chemical Synthesis of Drugs - Combinatorial Approaches
• Drug Discovery - An Overview
• Target Identification and Validation
• X-ray Crystallography in Drug Design
• Structure-based drug design - Principles and Methods
• Secretion in pro- and eukaryotes
• Structure, function biogenesis and stasis of membraneouse compartments of eukaryotes
• Cellular fusion, cytokinesis and organellar inheritence
• RNA-metabolism
• History of virology
• Virus taxonomy and structure
• Virus morphology in overview
• Viral life cycles (entry, assembly, budding)
• Replication mechanisms
• Viral evolution
• Basic techniques in virology and methods of virus diagnostics
• Blood-borne viruses and safety of blood products
• Biosafety classification of viruses according to “Gentechnikrecht” and “Biostoffverordnung”
• Pharmacology of Thyroid Homones
• Serendipity in the age of rational drug design: a case study

Qualification-goals/Competencies:

• Similar to the moduls LS4110A, LS4110B, LS4010A, LS4040: Students are able to explain the effects of therapeutic drugs on the organism (Pharmacodynamics).
• The are able to explain the time course of therapeutic drug concentrations in the organism (Pharmacokinetics).
• The are able to explain the mechanisms of action of various substance classes.
• The are able to explain the experimental methods in pharmacology
• The are able to explain the basic strategies of Drug Design.
• The are able to explain the the way from the target discovery to the drug. Techniques of rational Drug Design
• The are able to explain the the relationship between chemical structure and effect and the techniques for theoretical prognosis and experimental tests, particular x-ray crystallography and NMR-experiments
• The students should explain the borders of x-ray crystallography and NMR-experiments.
• Ability to link the newly communicated detailed cell biology knowledge with the already acquired knowledge and to apply it in the context of other modules.
• Ability, to recognize the connection between the cell biology of hosts and the molecular strategies of viral and other microbiological parasites.
• They can categorize viruses systematically.
• They can explain and compare viral life cycles and replication strategies.
• They can list basic practices and protocols for the virological safety of blood products.
• They can apply basics knowledge according to “Gentechnikrecht” and “Biostoffverordnung”.

Grading through:

• written exam

Responsible for this module:

• Prof. Dr. rer. nat. Enno Hartmann
• Prof. Dr. rer. nat. Thomas Peters

Teacher:

• Institute of Virology and Cell Biology
• Institute for Biology
• Institute of Chemistry and Metabolomics
• Institute of Experimental and Clinical Pharmacology and Toxicology
• Institute of Molecular Medicine
• Institute of Biochemistry
• Prof. Dr. rer. nat. Thomas Peters
• Prof. Dr. rer. nat. Olaf Jöhren
• PD Dr. rer. nat. Jan Wenzel
• Prof. Dr. rer. nat. Tobias Restle
• Prof. Dr. rer. nat. Rolf Hilgenfeld
• Prof. Dr. med. Markus Schwaninger
• Dr. med. Dirk Ridder
• Prof. Dr. rer. nat. Walter Raasch
• Prof. Dr. rer. nat. Norbert Tautz
• Dr. rer. nat. Olaf Isken
• Prof. Dr. rer. nat. Enno Hartmann
• Prof. Dr. rer. medic. Lisa Marshall
• Dr. rer. nat. Dipl.-Psych. Sonja Binder
• Prof. Dr. rer. nat. Enrico Leipold
• Dr. rer. nat. Marietta Zille
• Dr.rer.nat Sonja Petkovic
• Prof. Dr. Lars Redecke
• Dr. math. et dis. nat. Jeroen Mesters
• PD Dr. rer. hum. biol. Helge Müller-Fielitz

Literature:

• Brunton L, Knollmann B : Goodman & Gilman's The Pharmacologic Basis of Therapeutics McGraw-Hill Education; 14. Edition (1. November 2022) - ISBN-10: 1264258070
• Lüllmann H, Mohr K, Hein L, Ziegler A, Bieger D : Color Atlas of Pharmacology Thieme; 5. Edition (15. November 2017) - ISBN-10: 9783132410657
• G. Klebe : Wirkstoffdesign Spektrum-Verlag Heidelberg, 2009. ISBN 978-3-8274-2046-6
• A. Hillisch & R. Hilgenfeld, Birkhäuser : Modern Methods in Drug Discovery Basel, Boston, Berlin 2003, ISBN 3-7643-6081-X
• : Grundlagen- und Übersichtsartikel für beide Veranstaltungen
• Lodish : Molecular Cell Biology
• Alberts : Molecular Biology of the Cell
• S.J. Flint et al. : Principles of Virology: Molecular Biology, Pathogenesis, and Control of Animal Viruses American Society Microbiology, February 2009, 3rd Ed., ISBN: 978-1-55581-443-4

Language:

• offered only in English

Notes:

Last Updated:

17.02.2023