Module MA4661-KP08, MA4661
Genetic Epidemiology 2 (GenEpi2)
Duration
1 Semester
Turnus of offer
each summer semester
Credit points
8
Course of studies, specific fields and terms:
- Master CLS 2023, compulsory, MML with specialization in Genetic Statistics
- Bachelor CLS 2023, optional suject, mathematics
- Bachelor CLS 2016, optional subject, mathematics
- Master CLS 2016, compulsory, MML with specialization in Genetic Statistics
- Bachelor CLS 2010, optional subject, mathematics
- Master CLS 2010, optional subject, mathematics
Classes and lectures:
- Genetic Epidemiology 2 (practical course, 2 SWS)
- Genetic Epidemiology 2 (lecture, 2 SWS)
- Genetic Epidemiology 2 (exercise, 1 SWS)
Workload:
- 75 hours in-classroom work
- 30 hours exam preparation
- 135 hours private studies
Contents of teaching:
- Classical methods of genetic epidemiology: - Familial aggregation and heritability - Model-based linkage analysis - Model-free linkage analysis - Linkage analyses for quantitative phenotypes - Family-based association tests
- Current topics in genetic epidemiology, e.g.: - Association tests for rare variants - Analysis of Omics data - Polygenic scores - Mendelian randomization
- Analysis of genetic data using specialized software packages (such as PLINK and MERLIN): - Genome-wide association studies - Family studies (linkage and association analyses)
Qualification-goals/Competencies:
- Students will be able to name and describe the most important procedures for linkage and association analysis in family studies.
- They know current analysis methods in genetic epidemiology.
- They can perform elementary tests by hand and interpret the results.
- They will be able to use software for more complex testing procedures and interpret the results.
Grading through:
- Written or oral exam as announced by the examiner
Is requisite for:
Responsible for this module:
- Prof. Dr. rer. nat. Silke Szymczak
Teacher:
- Institute of Medical Biometry and Statistics
- Prof. Dr. rer. nat. Silke Szymczak
- MitarbeiterInnen des Instituts
Literature:
- Ziegler, Andreas; König Inke R (2010) : A Statistical Approach to Genetic Epidemiology. Concepts and Applications 2nd ed., Wiley-VCH: Weinheim
- Bickeböller, Heike; Fischer, Christine (2007) : Einführung in die Genetische Epidemiologie Springer: New York
- Recent review articles : (to be announced in lecture)
Language:
- offered only in German
Notes:
Admission requirements for taking the module:- None (The competencies of the modules listed under 'Requires' are needed for this module, but are not a formal prerequisite)
Admission requirements for participation in module examination(s):
- Examination prerequisites can be defined at the beginning of the semester. If preliminary work is defined, it must have been completed and positively evaluated before the first examination.
Module exam(s):
- MA4661-L1: Genetic Epidemiology 2, written exam (90 min) or oral exam (30 min), 100 % of module grade
- MA4661-L2: Practical Course Genetic Epidemiology 2, ungraded practical course, 0 % of module grade, must be passed
(Share of Institute of Medical Biometry and Statistics in V is 100%)
(Share of Institute of Medical Biometry and Statistics in Ü is 100%)
(Share of Institute of Medical Biometry and Statistics in P is 100%)
Last Updated:
18.02.2026