Module LS4130 A

Duration

1 Semester

Turnus of offer

each summer semester

Credit points

4

Course of studies, specific fields and terms:

• Master MES 2020, module part, mathematics / natural sciences
• Master Entrepreneurship in Digital Technologies 2020, module part, Module part
• Master Entrepreneurship in Digital Technologies 2014, module part, mathematics / natural sciences
• Master MES 2014, module part, mathematics / natural sciences
• Master MLS 2009, Module part of a compulsory module, structure biology

Classes and lectures:

• Basics of Membrane Biophysics (exercise, 1 SWS)
• Basics of Membrane Biophysics (lecture, 2 SWS)

Workload:

• 75 hours private studies
• 45 hours in-classroom work

Contents of teaching:

• Importance and function of cell membranes: structure, physical function and dynamic models
• Basics of the membrane components
• Thermodynamic self-assembling of lipids and reconstitution techniques
• Transmembrane and intrinsic membrane potentials
• Mechanical properties of lipid membranes
• Physical basics of membrane transport mechanisms
• Investigations using lipid monolayer
• Electrical and optical experiments using planar lipid bilayers
• Examples for interaction mechanisms between peptides/ proteins and planar membranes
• Spectroscopic methods on membranes and membrane proteins
• Light and force microscopy on membranes and membrane proteins

Qualification-goals/Competencies:

• The students can explain the components and the structure of biological membranes.
• They can explain the role and function of membrane lipids and proteins.
• They can explain the mechanical and electrical properties of membranes.
• They can explain the reconstitution of artificial lipid membranes.
• They can explain the methods for the investigation of artificial and natural membranes.
• They can explain the application of biophysical methods to biomedical questions, such as the characterization of membrane-active toxins.

Grading through:

• written exam

Responsible for this module:

• Siehe Hauptmodul

Teacher:

• Research Center Borstel, Leibniz Lung Center
• Prof. Dr. rer. nat. Thomas Gutsmann
• Prof. Dr. rer. nat. Andra Schromm
• Dr. Christian Nehls

Literature:

• Adam, P. Läuger, G. Stark : Physikalische Chemie und Biophysik Springer-Verlag, 4. Auflage 2003
• W. Hanke, R. Hanke : Methoden der Membranphysiologie Spektrum Akademischer Verlag, Auflage 1997
• Ole G. Mouritsen : Life - As a Matter of Fat Springer 2005, ISBN 987-3-540-23248-3
• Thomas Heimburg : Thermal Biophysics of Membranes Whiley-VCH 2007, ISBN 978-3-527-40471-1
• Lukas K. Buehler : Cell Membranes Garland Science 2016, ISBN 978-0-8153-4196-3

Language:

• English, except in case of only German-speaking participants

Notes:

Last Updated:

16.04.2021