Module ME3220-KP04, ME3220

Duration

1 Semester

Turnus of offer

each winter semester

Credit points

4

Course of studies, specific fields and terms:

• Bachelor MES 2020, optional subject, medical engineering science
• Master MES 2014, optional subject, medical engineering science
• Bachelor MES 2014, optional subject, medical engineering science

Classes and lectures:

• Therapeutische Laseranwendungen (lecture, 3 SWS)

Workload:

• 20 hours exam preparation
• 55 hours private studies and exercises
• 45 hours in-classroom work

Contents of teaching:

• The aim of the course is to learn about the effect of laser radiation on tissue with very different irradiance levels, i.e. to learn about it theoretically and to validate it experimentally in the laboratory using specific setups. The necessary lasers, laser parameters and various application techniques are discussed and applied for the corresponding effect classes, with the learning objectives listed below: - thermal tissue effects: light distribution, heating, thermal diffusion, coagulation, contractive forces due to phase transition. Examples: Laser thermokeratoplasty (thermal deformation of the cornea), skin tightening, hemostasis - Selective tissue effects: selective cell effects, thermo-mechanical transition, microvaporization, blistering, pressure transients. Examples: Selective cell effects on the retinal pigment epithelium of the eye without affecting the adjacent retina, selective laser trabeculoplasty for glaucoma treatment, removal of tattoos and port-wine stains - vaporizing tissue effect: thermal-vaporizing effects, various thermal edge zones (carbonization, coagulation, subnecrotic inflammation). Example: cutting of tissue - ablative tissue effect: photoablation, cavitation bubbles, pressure effects, ablation products. Example: laser lithotripsy (disintegration of ureteral stones) - disruptive tissue effect: laser-induced plasma, pressure waves, cavitation bubbles. Examples: Disruption of the post-sternal membrane on the lens capsule of the eye, refractive laser surgery

Qualification-goals/Competencies:

• Students learn laser light distribution in tissue as a function of absorption and scattering.
• The students learn the different mechanisms of action of laser light on tissue as a function of pulse duration and irradiance.
• The students learn the therapeutic possibilities in the different efficacy classes.
• The students learn the photocoagulation of the retina of the eye and the thermal coagulation of tissue as examples of thermal modes of action.
• The students learn selective retina therapy and tissue dissection as examples of vaporization effects.
• The students learn the laser-induced disintegration of hard concrements (ureter stones) as an example of photoablative mechanisms.
• The students learn refractive surgery and presbyopia prophylaxis as examples of plasma-mediated effects.
• The students learn different methods for real-time measurement of the laser effect on tissue, e.g. photoacoustics, spectroscopy, light reflection.
• Based on this, the students learn the real-time feedback to the treatment laser for intelligent, feedback laser therapy (Theragnostics).
• The students learn the application of all procedures in the wet lab in the laboratory on models.
• The students learn how to create an experimental protocol with a description of the method and presentation of the results.

Grading through:

• protocols

Responsible for this module:

• Prof. Dr. rer. nat. Robert Huber

Teacher:

• Institute of Biomedical Optics
• Dr. rer. nat. Ralf Brinkmann
• Dr. rer. nat. Norbert Linz

Literature:

• Brinkmann R, Knipper A, Dröge G, Schroer F, Gromoll B, Birngruber R. : Fundamental Studies of Fiber-Guided Soft Tissue Cutting by Means of Pulsed Midinfrared IR lasers and their Application in Ureterotomy J Biomed Optics 1998; 3(1):85-95
• Theisen-Kunde D, Ott V, Brinkmann R, Keller R. : Potential of a new cw 2µm laser scalpel for laparoscopic surgery Medical laser application 2007; 22:139-145
• Brinkmann R, Birngruber R. : Selektive Retina-Therapie (SRT) Z Med Phys 2007; 17:6-22
• Brinkmann R, Koinzer S, Schlott K, Ptaszynski L, Bever M, Baade A, Luft S, Miura Y, Roider J, Birngruber R. : Real-time temperature determination during retinal photocoagulation on patients J Biomed Opt 2012; 17(6): 061219
• Lange B, Cordes J, Brinkmann R. : Stone/Tissue Differentiation for Holmium Laser Lithotripsy using Autofluorescence Las Surg Med 2015; 47(9):737-744
• König, K. : Handbook of Biological Confocal Microscopy Third Edition, edited by James B. Pawley, Springer Science+Business Media, LLC, New York, 2006

Language:

• offered only in German

Notes:

Last Updated:

31.03.2025