Module LS4175 B

Duration

1 Semester

Turnus of offer

each summer semester

Credit points

3

Course of studies, specific fields and terms:

• Master Infection Biology 2018, Module part of a compulsory module, Microbiology
• Master Infection Biology 2012, Module part of a compulsory module, Microbiology
• Master Infection Biology 2023, Module part of a compulsory module, Microbiology

Classes and lectures:

• Mechanisms of Bacterial Pathogenicity (seminar, 2 SWS)

Workload:

• 30 hours in-classroom work
• 60 hours private studies

Contents of teaching:

• Historical background: Milestones in the discovery of the factors involved in microbial virulence
• Invasiveness, toxigenesis, colonization, specific adherence
• Structure of bacterial cell membrane, cell wall and cell surface: Gram-positive and Gram-negative bacteria, mycobacteria, virulence factors
• Structure and biosynthesis of lipopolysaccharides
• Structure and biosynthesis of lipoarabinomannan
• Structure, biosynthesis and functions of mycobacterial lipids
• Recognition of microbial virulence factors by pattern recognition receptors
• Recognition of lipids by immune cells, the role of CD1 presentation
• Microbial toxins (e.g., leucocidin, hemolysin, botulinum toxin, diphtheria toxin, anthrax toxin, tetanus toxin, pertussis toxin, cholera enterotoxin, adenylate cyclase, Staphylococcus aureus enterotoxin, TSST, superantigen, shiga toxin, Escherichia coli LT toxin, ST toxin)

Qualification-goals/Competencies:

• Competence in critical reading, discussing and presenting research articles
• Student can explain structures and biosynthetic pathways of microbial constituents responsible for microbial virulence
• Student can explain virulence mechanisms of pathogenic microorganisms
• Student can evaluate the quality of experimental data
• Student can present a research paper / topic in a seminar setting
• Student can conduct literature researches using Pubmed

Grading through:

• see Notes

Responsible for this module:

• Siehe Hauptmodul

Teacher:

• Research Center Borstel, Leibniz Lung Center
• Prof. Dr. rer. nat. Otto Holst
• Priv.-Doz. Dr. rer. nat. Sven Müller-Loennies

Literature:

• n.n. : Provided research articles and own literature research

Language:

• offered only in English

Notes:

Last Updated:

01.11.2020